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Breastfeeding Beneficial for your Child

Breastfed kids are smarter, according to a Harvard University study that found the longer babies are nursed, the greater their intelligence.
The research, which followed more than 1,000 women and their babies, found that each additional month a child was breastfed resulted in better language skills at 3 years old and intelligence at age 7, compared with babies not breastfed. The findings are published in the journal JAMA Pediatrics.

The study is one of the largest to look at the role of breastfeeding on a child’s intelligence, the authors said. It also underscores the need to support mothers in the workplace and in public to enable them to breastfeed their babies during the first year of life, said Dimitri Christakis, who wrote an accompanying editorial in the journal.
“With this we can close the book and decide there is a link between child breastfeeding and intelligence,” said Christakis, a professor of pediatrics at Seattle Children’s Research Institute, a pediatric medical research center, in a July 26 telephone interview. “The fact that breastfeeding really promotes cognition in our children is something we should all care about. It takes a village to breastfeed a child. We should take the actions necessary not to just initiate breastfeeding but to sustain it.”
Still, breastfeeding is not the only contributing factor to intelligence, said Mandy Belfort, the lead study author and a neonatologist at Boston Children’s Hospital and an assistant professor of pediatrics at Harvard Medical School.
“It’s important to point out that breastfeeding is just one factor that influences a child’s intelligence,” Belfort said in a July 26 interview. “Our results shouldn’t make parents feel bad for the choice they have made.”

Doctor Recommendations

The American Academy of Pediatrics suggests exclusive breastfeeding for six months after birth before adding food, and that mothers continue to nurse until their child is at least 1 year old.
In the U.S., about 77 percent of women whose babies were born in 2009 started breastfeeding when their child was born, that number dropped to 47 percent at 6 months of age and 26 percent at 12 months, according to the U.S. Centers for Disease Control and Prevention.
It’s not known how breast milk benefits intelligence, Belfort said. It may be nutrients in the milk help the developing brain or the way mom and baby interact during breastfeeding, she said. More studies are needed to better understand the relationship.

‘Scientific Basis’

“I hope our findings provide a scientific basis for women to make choices about not only whether to breastfeed or not, but for how long to continue breastfeeding,” she said.
Belfort said parents also should speak to their babies, including newborns, and expose them to a lot of language to help promote language development.
Researchers in the study followed more than 1,000 pregnant women and their babies until the children were age 7. After controlling for maternal intelligence, they found that IQ scores for 7 year olds increased by about one-third of a point for every month of breastfeeding. That means a 7-year-old child who was breastfed as a baby for 12 months would score four points higher on intelligence tests than a child who was never breastfed, Belfort said.
There was no association between breastfeeding and visual motor skills or visual memory, the authors said.
The findings also hinted that children’s intelligence benefited when their moms ate more fish while breastfeeding then those who ate less fish, but the results weren’t statistically significant, Belfort said.
“Individual women should use this as one further incentive to breastfeed their children,” Christakis said.
The research was supported by grants from the National Institutes of Health.
Source:bloomberg

Women's breasts age faster than the rest of their body

The question "how old are you?" just became a lot harder to answer <i>(Image: REX/Cultura)</i>
Breasts typically age more quickly than the rest of the female body. So suggests a system that may be the most accurate way yet of identifying a person's age from a blood or tissue sample.
As we age, the pattern of chemical markings on our DNA changes. Each gene becomes more or less methylated, that is, they have methyl chemical groups added or removed. This generally increases or decreases gene expression. The whole process is known as epigenetics.
Steve Horvath at the University of California, Los Angeles, and his colleagues have used these changes to estimate a person's age. To do so, they first performed a detailed statistical analysis of methylation patterns in 7844 healthy tissue samples from 51 different types of tissue. The tissue covered a range of ages – from fetuses to people 101 years old.

Universal ageing

The analysis allowed the team to weed out methylation patterns that varied between tissues, leaving just those that are common to all tissues. This enabled them to identify a subset of 353 specific regions of the genome that became either more or less methylated with age in almost all types of tissue.
By measuring the total amount of methylation in these regions, the team was able to create an algorithm that identified the age of the tissue.
The team validated the algorithm against thousands more samples of known age. Horvath says the method is twice as accurate as the next best method of ageing tissue, which is based on the length of telomeres – tips of chromosomes that "burn down" with age like candle wicks. He says that his method has a 96 per cent chance of accurately identifying someone's age to within 3.6 years compared with around 53 per cent for telomeres.
"What's unique about this study is the idea that there's a signature of ageing common across tissues in spite of the significant tissue specificity of DNA methylation patterns," comments Moshe Szyf, who studies methylation at McGill University in Montreal, Canada. "The data point to the possibility that DNA methylation signatures could be used as robust markers of biological ageing."

Young at heart

Horvath says that, remarkably, their analysis shows that some parts of the body age at different rates. When they used their algorithm on healthy breast tissue from a group of women of average age 46, for example, it churned out a result that was on average two to three years older than the woman's actual age. Whereas in two groups aged 55 and 60 across both sexes, heart tissue appeared nine years younger than true age.
If it is known where the sample comes from, it is still possible to accurately predict age after some straightforward adjustment, says Horvath. However, in general, the algorithm is most accurate for samples from people under 30 years of age. "The older one gets, the less accurate it becomes," he says.
Horvath thinks that breast tissue ages more quickly because of its constant exposure to hormones. Heart tissue may remain younger, by contrast, because it is constantly regenerated by stem cells.
Cancerous tissue also appeared to age prematurely, coming out at 36 years older than the person's actual age on average across 20 cancers from 20 different organs.
Because ageing is a risk factor for all cancers, Horvath suggests that the premature ageing of breast tissue might explain why it is the most common cancer in women. "It could be so prevalent because that part of the female body is older," he says.

Blood work

Because the method also works on blood it might have the potential to be used forensically, to reveal the age of a murder suspect, suggests Horvath. It might also be used to diagnose cancer, by revealing accelerated ageing in tissue biopsies.
"The data raises questions about whether these DNA methylation changes play a causal role in ageing and, if so, whether epigenetic interventions could reverse these and therefore slow down ageing," says Szyf. "The chemical robustness of DNA methylation and the ability to accurately measure it make it a very attractive tool to study ageing, which could well be superior to measuring telomere length, which is the current practice."
Horvath says that further studies comparing telomere and epigenetic ageingcould be useful, and hopes the two can be complementary. He also says that the software for his algorithm is openly available so that other researchers can try validating it on their own tissue samples.

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